Peptides are small chains of amino acids that have been a primary focus for researcher, clinician, and scientists over the last decade because of their ability to stimulate and communicate with hormones. When supplemented under the guidance of a certified professional, peptide therapy can stimulate secretion of hormones that regulate vital body processes such as metabolism, sleep, repair, recovery, energy, fat-burning, and more.
Peptide Therapy Products at Modern Wellness Clinic
5-Amino-1MQ has been shown in research to address age-related decline in fat-burning capacity. Adequate dosing and pairing 5-Amino-1MQ with a complementary treatment plan typically restores the body’s natural ability to burn excess fat. 5-Amino-1MQ naturally reduces the concentrations of nicotinamide N-methyltransferase (NNMT), facilitating weight loss and better health in older adults.
About 5-Amino-1MQ 5-Amino-1MQ is a small, selective, membrane permeable molecule that is an inhibitor of nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that plays a role in cellular metabolism and energy homeostasis. NNMT has been found to be upregulated in white adipose tissue of mice compared to other tissues, thus, NNMT is an ideal target for an anti-obesity medication. 5-amino-1MQ is a derivative of methyl quinolinium (MQ) which has exhibited a high efficacy in NNMT inhibition, cell viability, and membrane permeability. It does not have any effect on the activity of any other enzymes in the relevant metabolic cycles, therefore reducing the risks of potential side effects. This NNMT inhibitor could be used to prevent adipogenesis and type II diabetes and reverse diet-induced obesity as a result of increased intracellular NAD+ and SAM.
About ARA-290 (Cibinetide Acetate) ARA-290 is a peptide currently being researched for its safety and efficacy for the treatment of neuropathic pain in patients with sarcoidosis, as well as its potential for disease modification and long-term support functional improvement in this condition
About BPC-157 Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally, it has been demonstrated to accelerate the healing of many different wounds, including tendonto-bone healing and superior healing of damaged ligaments.
CJC 1295 acts on the pituitary gland to maximize levels of growth hormone in the body. Increased volume of human growth hormone (hGH) production in the pituitary gland supports increased production of insulin-like growth factor (IGF-1) by the liver and results in multiple health benefits.
About CJC 1295
CJC 1295 is a tetrasubstituted 29-amino acid peptide hormone, primarily functioning as a growth hormone releasing hormone (GHRH) analog. CJC 1295 outperforms the older and outdated GHRH, Sermorelin. The half-life of Sermorelin ranges from 8-12 minutes, whereas the half-life of CJC 1295 extends to 30 minutes. Sermorelin’s efficacy decreases with time and the body produces antibodies to Sermorelin, bioconjugate with serum albumin, thus increasing its half-life and potential therapeutic window. It accomplishes this by using protecting groups around the amino acids of GHRH typically susceptible to enzymatic degradation, thus increasing the half-life. Consequently CJC 1295 without DAC is designed to provide a GHRHlike stimulation around the clock with increased amplitude and longer stimulation, (28 minutes instead of 8-12 of sermorelin), maintaining the natural pulsatile stimulation of the pituitary without decreasing secretion as observed in CJC with DAC.
Dihexa is a known as a cognitive enhancer. It is a peptide designed to support certain cognitive functions, help improve mental stamina, and short-term and long-term memory capacity. In some cases, Dihexa has been shown to support treatment for dementia, Alzheimer’s and other conditions or traumas that impact the brain, including helping repair brain damage.
Dihexa is a peptide variant derived from angiotensin IV which has been found to potentially improve cognitive function in animal models of diseases such as Alzheimer’s. Angiotensin IV is a derivative of the potent vasoconstrictor angiotensin II and has been shown to enhance acquisition, consolidation, and recall of learning and memory in animal models when administered centrally or peripherally. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than BDNF. It could possibly help in the repair of the brain and nerves in neurological disease.
Ipamorelin is among the widely sought-after peptide therapies. It supports the release of growth hormone (GH) by mimicking ghrelin. By acting on the pituitary gland, ipamorelin elevates a “pulse” duration of GH—delivering a longer duration after administration compared to other growth hormone releasing peptides. Ipamorelin stimulates production of insulin-like growth factor (IGF-1) as well, further enhancing anti-aging, athletic, and total health benefits. In conjunction with the right treatment plan, ipamorelin has been shown to decrease body fat, improve weight loss, muscle recovery, promote better sleep, and enhance immune function, cellular repair and collagen production.
About Ipamorelin Ipamorelin is a selective GH-Secretagogue and ghrelin receptor agonist. The potency of ghrelin stimulation can be compared to GHRP6 with less appetite stimulation properties. However, unlike other GH-Secretagogues this pentapeptide doesn’t release the same volumes of cortisol, acetylcholine, prolactin, and aldosterone. It is for this reason Ipamorelin has been considered the first selective GH Secretagogue.
LL-37 is commonly called, “the little peptide with big uses.” It has been shown to have antimicrobial effects against infection, including MRSA and HIV. It is also useful for chronic wound healing and inflammatory conditions of the GI tract. There has been evidence that LL-37 is helpful in the treatment of certain cancers, but that list is heavily limited to colon cancer, gastric cancer, hematologic malignancy, and oral squamous cell carcinoma. LL37 is reported to induce tumorigenic effects in cancers.
About LL-37 Cationic host defense peptides such as LL-37 are key components of innate defenses against infection, with both microbicidal and host defense modulatory functions. In addition to their well-described bactericidal potential, CHDP have more recently been shown to have antiviral properties. LL-37 has been shown to be highly effective in preventing viral attachment to cells. Used in several virus studies and has been anecdotally reported to work well with respiratory tract viruses. Caution in patients with known autoimmune disorders. Worsening auto-immune symptoms have been reported with LL-37
Shown in research to be one of the most potent and highly effective selective androgen receptor modulators (SARM), LGD-4033, creates anabolic activity in the bones and muscles. This function makes LGD-4033 an effective treatment option to support strength, increased lean muscle mass, exercise recovery, and reduced body fat.
LGD-4033 has a safe, favorable pharmacokinetic profile, and increases lean body mass without change in prostatespecific antigen. In research studies, hemoglobin, prostatespecific antigen, aspartate aminotransferase, alanine aminotransferase, or QT intervals did not change significantly at any dose. LGD-4033 had a long elimination half-life and dose-proportional accumulation upon multiple dosing. LGD-4033 administration is typically associated with dose-dependent suppression of total testosterone, sex hormone–binding globulin, high density lipoprotein cholesterol, and triglyceride levels. Follicle-stimulating hormone and free testosterone showed significant suppression at 1.0-mg dose only
Melanotan is a peptide that increases the amount of melanin in the skin to support protection against UV rays and induce skin tanning. Other benefits associated with Melanotan II include increased sexual desire, appetite control, neuroprotection, cardiovascular health support, and treatment for erythropoietic protoporphyria. Patients with a history of melanoma or at high-risk of melanoma are not good candidates.
About Melanotan II Melanotan II is an analogue of the peptide hormone alpha-melanocytestimulating hormone (a-MSH) that induces skin tanning. It was originally developed by the University of Arizona in the 1980s to treat people who were intolerant to the sunlight. Melanotan II plays a role in melanogenesis in protecting the skin from UV light. There are five melanocortin receptors each with a different function. MT 2 binds primarily to MC-4R and MC-1R, and weakly to MC-3R.
MK-677 is known to improve growth hormone levels and impact the area of the brain that controls appetite, mood, memory, and cognition. The benefits of MK-677 in conjunction with complementary therapies are shown to support musclebuilding, reduce muscle wasting, improve bone density, promote better sleep, and support anti-aging effects related to growth hormone deficiencies.
About MK-677 MK-677 is a long active orally bioactive agonist of the GHSR1a. As such, it binds to the same receptor that GHRP2, GHRP6, and Ipamorelin also stimulate. Also called Ibutamoren, it has shown to cause a predictable rise in IGF-1 but unlike other GH secretagogues, it doesn’t help to decrease adipose tissue. It has been shown to increase lean muscle mass and might be a good candidate for sarcopenic patients with low bone mineral density. To reduce the negative effect of somatostatin, MK-677 is best taken on an empty stomach with no insulin in the system
PT-141, also known as Bremelanotide, is an innovative peptide hormone treatment shown to be effective for improving sexual function in men and women. PT-141 supports treatment of erectile dysfunction and increased libido in men and improves female sexual arousal disorder in women. PT-141 works directly through the nervous system to increase arousal, desire, and satisfaction with sex. PT-141 peptide induces desire and motivation for sex, increases blood flow to the penis or vagina and clitoris.
About PT-141 (Bremelanotide) Bremelanotide (PT-141) is a derivative of the peptide hormone, Melanotan II. In initial testing, Melanotan II induced darkening of skin pigment, but additionally caused sexual arousal and spontaneous erections as unexpected side effects in nine out of the ten original male volunteer test subjects. Further testing in animals showed Bremelanotide to induce lordosis (a sexual mating behavior) and subsequently tested for its effect in humans. Although, most of the research has been targeted to women with female sexual dysfunction and it is effective medication in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder)
Selank is classified as a synthetic peptide because it is made by combining the sequence of the peptide tuftsin with another peptide to improve molecular stability. In research, Selank has been shown to reduce anxiety, improve learning a