.png)
NAD+ is a coenzyme your cells can’t function without — and its levels drop by up to 50% between ages 40 and 60. NAD+ therapy replenishes what age, stress, and metabolic dysfunction deplete. Here’s the science and what patients actually experience.
March 18, 2026
If you’ve read anything about longevity science in the past decade, you’ve likely encountered NAD+. It’s become one of the most discussed molecules in anti-aging research — for good reason. NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell in your body, and it’s involved in more fundamental biological processes than almost any other molecule. Understanding what it does — and what happens when it declines — explains why NAD+ therapy is producing the results it does in the patients we treat at Modern Wellness Clinic in Summerlin, Las Vegas.
NAD+ has two primary roles in cellular biology. First, it’s essential for the electron transport chain — the process inside mitochondria that converts the food you eat into ATP, the currency your cells actually run on. Without adequate NAD+, this process becomes less efficient, and cells simply can’t produce energy at the rate the body demands. This is why NAD+ depletion is experienced as fatigue that doesn’t respond to sleep or rest.
Second, NAD+ is the substrate for a family of enzymes called sirtuins — proteins that regulate gene expression, inflammation, stress resistance, and mitochondrial function in ways that are directly linked to longevity and healthy aging. Sirtuins can’t function without NAD+. When NAD+ declines, sirtuin activity declines with it, and the regulatory functions they perform begin to deteriorate. NAD+ also serves as a substrate for PARP enzymes, which are responsible for detecting and repairing damaged DNA strands — a process that becomes increasingly important as we age and accumulate more oxidative damage.
NAD+ levels decline predictably with age — roughly 50% between ages 40 and 60 in most studies. But aging isn’t the only driver. Alcohol consumption depletes NAD+ significantly. Chronic stress increases NAD+ consumption through PARP activation. Poor sleep reduces mitochondrial efficiency and impairs NAD+ recycling. And certain metabolic conditions, including obesity and insulin resistance, are associated with chronically lower NAD+ levels. In Las Vegas specifically, where chronic dehydration, alcohol exposure, irregular sleep, and high-stress occupations are common, NAD+ depletion tends to compound.
We offer NAD+ through three delivery methods, each appropriate for different situations. IV infusion delivers NAD+ directly into the bloodstream — the highest bioavailability option, used for loading protocols and patients who want the most complete systemic effect. Sessions run 1–3 hours depending on dose and tolerance. Subcutaneous injection is an at-home option that bypasses digestive degradation while allowing patients to maintain their protocol between in-clinic sessions. Intranasal spray is our between-session maintenance option for established NAD+ patients.
Most patients begin with a loading series — typically 3–5 sessions over 1–2 weeks — to restore NAD+ levels before transitioning to a maintenance schedule. Some patients notice improvements in energy and mental clarity after the first session or two; the full benefit of the loading protocol typically develops over 2–4 weeks as cellular function improves.
The most consistent reports from our Las Vegas patients after a NAD+ loading protocol: improved mental clarity and cognitive sharpness, better sustained energy without the peaks and crashes of stimulants, improved sleep quality and depth, faster recovery from physical activity, and — in patients in addiction recovery — reduction in cravings and improved neurological stability. NAD+ infusions can cause mild flushing, warmth, or nausea during administration; these are managed by adjusting the infusion rate and resolve quickly.
The patients at Modern Wellness Clinic who see the most meaningful results from NAD+ therapy tend to be adults in their 40s and 50s pursuing longevity and performance optimization, patients dealing with burnout or post-illness energy depletion, athletes focused on recovery, and patients in addiction recovery where neurological restoration is a clinical goal. NAD+ pairs well with IV vitamin therapy, peptide protocols, and hormone optimization for patients pursuing comprehensive longevity programs.
To schedule a NAD+ consultation at Modern Wellness Clinic in Summerlin, call (702) 463-9159 or visit 5375 S Fort Apache Rd, Las Vegas, NV 89148. Telehealth consultations are available for Nevada patients to discuss whether NAD+ therapy is appropriate for your situation. Learn more on our NAD therapy service page.
.png)